%0 Journal Article
%T Highlighting of a new xanthine derivatives DDP4 inhibitor for diabetes mellitus drugs using Virtual screening.
%A El Hassen MOKRANI
%A Abderrahmane BENSEGUENI
%A Abdelouahab CHIKHI
%A Soumia TENIOU
%J Technologies de Laboratoire
%D 2012
%I TECHNOP
%X Virtual screening by molecular docking is a new approach aims to simulate and predict the affinity of a very large number of ligands for the active site of a given therapeutic target, which is considerably easier to implement, cheaper and faster than the use of experimental methods. Initiated in the beginning of 1980, this approach has developed to became, today, an essential tool for bioactive molecules¡¯ research. This Work consists to screen of, with AutoDock, a collection of 2558 molecules dispensable in PubChem database, towards the active site of dipeptidyl peptidase 4: recent enzyme target, playing a promising role in diabetes mellitus treatments. This enzyme serves to degrade incritin hormones, especially GLP1 and GIP, that stimulate, to them only, about 60 % of insulin¡¯s secretion in the blood. So, by blocking the active site of DPP4, we can extend the duration of action of natural incretin¡¯s hormones and contribute to normalize blood sugar levels for type 2 diabetics.
%K AutoDock
%K Dipeptidyl-peptidase 4
%K Molecular docking
%K inhibitor
%K Virtual screening
%U http://revues.imist.ma/index.php?journal=technolab&page=article&op=view&path%5B%5D=581&path%5B%5D=479