%0 Journal Article
%T High resolution human leukocyte antigen (HLA) class I and class II allele typing in Mexican mestizo women with sporadic breast cancer: case-control study
%A David Cant迆 de Le車n
%A Delia P谷rez-Montiel
%A Ver車nica Villavicencio
%A Alejandro Carranca
%A Alejandro Betancourt
%A Victor Acuˋa-Alonzo
%A Alberto L車pez-Tello
%A Gilberto Vargas-Alarc車n
%A Rodrigo Barquera
%A Neng Yu
%A Edmond J Yunis
%A Julio Granados
%J BMC Cancer
%D 2009
%I BioMed Central
%R 10.1186/1471-2407-9-48
%X We designed a case-control study to quantify the association of HLA class I and II genes and breast cancer. HLA typing was performed by high resolution sequence-specific oligotyping after DNA amplification (PCR-SSOP) of 100 breast cancer Mexican mestizo patients and 99 matched healthy controls.HLA-A frequencies that we were able to observe that there was no difference between both groups from the statistical viewpoint. HLA-B*1501 was found three times more common in the case group (OR, 3.714; p = 0.031). HLA-Cw is not a marker neither for risk, nor protection for the disease, because we did not find significant statistical differences between the two groups. DRB1*1301, which is expressed in seven cases and in only one control, observing an risk increase of up to seven times and DRB1*1602, which behaves similarly in being present solely in the cases (OR, 16.701; 95% CI, 0.947 每 294.670). DQ*0301-allele expression, which is much more common in the control group and could be protective for the presentation of the disease (OR, 0.078; 95% CI, 0.027每0.223, p = 0.00001).Our results reveal the role of the MHC genes in the pathophysiology of breast cancer, suggesting that in the development of breast cancer exists a disorder of immune regulation. The triggering factor seems to be restricted to certain ethnic groups and certain geographical regions since the relevant MHC alleles are highly diverse. This is the first study in Mexican population where high resolutions HLA typing has been performed in order to try to establish an association with malignancy.Breast cancer is a common neoplasm around the world with almost 1 million cases diagnosed every year, it is also considered the most frequent malignant neoplasm in developed countries, globally accounts for 18% of all female cancers [1]. In Mexico, this neoplasm occupies second place, preceded only by cancer of the cervix, which occupies 10.6% of all tumors and 16.4% of all tumors in women. It is considered that the combinati
%U http://www.biomedcentral.com/1471-2407/9/48