%0 Journal Article
%T Differential expression of topoisomerase II¦Á protein in salivary gland carcinomas: histogenetic and prognostic implications
%A Shin-ichiro Maruya
%A Takashi Shirasaki
%A Takahiko Nagaki
%A Seiji Kakehata
%A Hidekachi Kurotaki
%A Hiroki Mizukami
%A Hideichi Shinkawa
%J BMC Cancer
%D 2009
%I BioMed Central
%R 10.1186/1471-2407-9-72
%X The protein expression of topoII¦Á was evaluated immunohistochemically in formalin-fixed, paraffin-embedded tissue from 54 salivary gland carcinomas and 20 benign tumors (10 pleomorphic adenomas and 10 Warthin's tumors). The primary salivary gland carcinoma specimens consisted of 17 adenoid cystic carcinomas, 7 adenocarcinomas not otherwise specified, 7 mucoepidermoid carcinomas, 6 salivary duct carcinomas, 3 acinic cell carcinomas, 3 carcinomas ex pleomorphic adenomas, 3 epithelial-myoepithelial carcinomas, 2 carcinosarcomas, 2 lymphoepithelial carcinomas, 2 myoepithelial carcinomas, 1 oncocytic carcinoma, and 1 squamous cell carcinoma. The associations between clinicopathological factors and outcome were analyzed.Of the 54 primary salivary gland carcinomas, 38 (70%) showed positive expression (¡Ý10%) of topoII¦Á protein, and 16 carcinomas (30%) and all benign tumors were negative (p < 0.001). Expression of topoII¦Á was more frequently observed in salivary duct carcinoma, carcinoma ex pleomorphic adenoma, adenocarcinoma, and adenoid cystic carcinoma, solid type, and it was associated with advanced stage and shortened survival.The results of the present study suggest that topoII¦Á expression is associated with histologically aggressive subtypes and shortened survival. Furthermore, it may provide useful prognostic information and suggests the potential efficacy of topoII¦Á-targeting therapy in patients with salivary gland carcinoma.Salivary gland carcinomas are uncommon neoplasms, accounting for approximately 5% of those arising in the head and neck region [1]. These tumors are characterized by widely varied histological features with heterogeneous and unpredictable clinical behaviors. In general, these carcinomas may be categorized into low grade and high grade malignancies based on their origin from either the terminal (intercalated) or the excretory ductal epithelium, respectively [2]. Biological and clinical classifications have been dependent on this histogenetic clas
%U http://www.biomedcentral.com/1471-2407/9/72