%0 Journal Article
%T The prognostic value of four interleukin-1 gene polymorphisms in caucasian women with breast cancer ¨C a multicenter study
%A Christoph Grimm
%A Eva Kantelhardt
%A Georg Heinze
%A Stephan Polterauer
%A Robert Zeillinger
%A Heinz K£¿lbl
%A Alexander Reinthaller
%A Lukas Hefler
%J BMC Cancer
%D 2009
%I BioMed Central
%R 10.1186/1471-2407-9-78
%X We studied the influence of four common gene polymorphisms (IL1A -889C/T, IL1B -511C/T, IL1B +3953E1/E2, and IL1RN long/2) of the IL-1 family on survival in 262 Caucasian patients with breast cancer by univariate and multivariate survival analysis. The combined effect of the four gene polymorphisms on overall survival was studied by haplotype analysis.In the present study 38 cases of cancer related death and a median time of follow-up (range) of 55.3 (0.4¨C175.8) months was observed. IL1RN 2/2 (homozygous mutant) gene polymorphism was associated with shortened disease free and overall survival in a univariate (p = 0.001 and p = 0.01, respectively) and multivariate analysis (p = 0.002, Odds Ratio [95% Confidence Interval] = 3.6 [1.6¨C8.0] and p = 0.05, Odds Ratio = 3.0 [1.1¨C9.3], respectively). Presence of the homozygous mutant genotype of the IL1A -889 and IL1B +3953 gene polymorphism was associated with overall survival in the univariate (p = 0.004 and p = 0.002, respectively), but not in the multivariate analysis. No association was observed between all possible haplotype combinations and overall survival.Carriage of the mutant alleles of IL1RN was independently associated with shortened disease free and overall survival rates in Caucasian patients with breast cancer.The interleukin-1 (IL-1) family consists of the cytokines, IL-1alpha (IL-1a), IL-1beta (IL-1b) and a specific receptor antagonist (IL-1RA) [1]. IL-1a and IL-1b are involved in various physiological and patho-physiological processes such as modulating the host response to microbial invasion, inflammation, and tissue injury [2]. IL-1RA neutralizes IL-1 action by binding to the IL-1 receptors (IL-1RI and IL-1RII) [3].In addition to its role in inflammatory processes, IL-1 has been extensively studied in various malignancies. Expression of IL-1 has been described in breast cancer tissue [4,5] as well as several other tumor tissues [6,7]. Its production and release by tumor cells results in an autocrine and
%U http://www.biomedcentral.com/1471-2407/9/78