%0 Journal Article %T Efficacy of opioid switching in asian 51-year-old man with a phenomenon of pharmacokinetics tolerance: case report %A C. Costa %A I. Paladina %A M. Del Zompo %J Pathos : Trimestrale di Algologia %D 2012 %I Publiediting %X Opioid switching is a therapeutic procedure used in pain management as a method to improve analgesicresponse and/or reduce adverse side effects. The rationale behind opioid substitution is the incomplete crosstolerance between opioid. We report the case of an asian 51-year-old man withcancer pain unresponsive to oxycodone. In this case we hypothesize that the lack of response to oxycodone is linked to a phenomenon of pharmacokinetics tolerance. %K Opioids %K switching %K side effects %U http://www.pathos-journal.com/doc/Efficacia_dello_switching.pdf