%0 Journal Article
%T The role of tumor necrosis factor-receptors in pregnancy with normal and adverse outcome
%A Calleja-Agius J
%A Muttukrishna S
%A Jauniaux E
%J International Journal of Interferon, Cytokine and Mediator Research
%D 2012
%I Dove Medical Press
%X Jean Calleja-Agius1, Shanthi Muttukrishna2, Eric Jauniaux11Academic Department of Obstetrics and Gynaecology, University College London Institute for Women's Health, WC1E 6HX London, United Kingdom; 2Anu Research Centre, University College Cork, Department of Obstetrics and Gynaecology, Fifth Floor, Cork University Maternity Hospital, Wilton, Cork, Republic of IrelandAbstract: TNF¦Á receptors, TNF-R1 and TNF-R2, mediate the biological activities of the multifunctional cytokine, tumor necrosis factor alpha, TNF¦Á. These receptors have a central role in human pregnancy. Although each receptor induces distinct intracellular signals, they also have co-operative and overlapping effects. The membrane bound TNF-R1 carries out most of the pro-inflammatory activities of TNF¦Á, especially those that are rapid, while TNF-R2 is involved in the late long-term effects of this cytokine. The soluble forms of these receptors can bind to TNF¦Á, neutralizing its effects. In normal human pregnancy, TNF¦Á receptors are present in the maternal circulation, placenta, amniotic fluid, and coelomic cavity. Changes in TNF¦Á and its receptors are associated with adverse pregnancy outcomes, including miscarriage, preterm labor and preeclampsia. Advances in anti-TNF¦Á therapy may have potential use in the management of complicated pregnancies.Keywords: TNF¦Á receptors, pregnancy, miscarriage, preeclampsia, preterm labor
%U http://www.dovepress.com/the-role-of-tumor-necrosis-factor-receptors-in-pregnancy-with-normal-a-a9191