%0 Journal Article
%T Prognosis and treatment of locally recurrent breast cancer
%A J Dunst
%J Breast Cancer Research
%D 2001
%I BioMed Central
%R 10.1186/bcr348
%X A major goal of treatment for locoregionally recurrent breast cancer is to achieve local control at the recurrent site. This includes surgery and/or radiotherapy. For local control, the patterns of local spread (scar or outside scar, multifocality, size, site) are important. In irresectable lesions, the addition of hyperthermia to radiotherapy yields improved local control. Encouraging local control rates have also been reported from some phase II studies with concurrent radiochemotherapy. In general, patients with local control at the recurrent site have a significantly better long-term prognosis as compared with patients with re-recurrence.Local recurrence is often associated with subsequent occurrence of distant metastases. Prophylactic ('adjuvant') systemic treatment is theoretically justified, but its impact on prognosis is unclear. Hormonal treatment is recommended if the recurrence is positive for ER/PR receptors. The use of chemotherapy is currently being investigated in several multicentre studies.
%U http://breast-cancer-research.com/content/3/S1/A23