%0 Journal Article
%T Identification of viral infections in the prostate and evaluation of their association with cancer
%A Margarita L Martinez-Fierro
%A Robin J Leach
%A Lauro S Gomez-Guerra
%A Raquel Garza-Guajardo
%A Teresa Johnson-Pais
%A Joke Beuten
%A Idelma B Morales-Rodriguez
%A Mario A Hernandez-Ordo£żez
%A German Calderon-Cardenas
%A Rocio Ortiz-Lopez
%A Ana M Rivas-Estilla
%A Jesus Ancer-Rodriguez
%A Augusto Rojas-Martinez
%J BMC Cancer
%D 2010
%I BioMed Central
%R 10.1186/1471-2407-10-326
%X 130 subjects (55 prostate cancer cases and 75 controls) were enrolled in the study. DNA and RNA isolated from prostate tissues were screened for the presence of viral genomes. Genotyping of the RNASEL R462Q variant was performed by Taqman method.R/R, R/Q, and Q/Q frequencies for R462Q were 0.62, 0.38, and 0.0 for PC cases and 0.69, 0.24, and 0.07 for controls, respectively. HPV sequences were detected in 11 (20.0%) cases and 4 (5.3%) controls. XMRV and HCMV infections were detected in one and six control samples, respectively. The risk of PC was significantly increased (Odds Ratio = 3.98; 95% CI: 1.17-13.56, p = 0.027) by infection of the prostatic tissue with HPV. BKV, JCV, and SV40 sequences were not detected in any of the tissue samples examined.We report a positive association between PC and HPV infection. The 462Q/Q RNASEL genotype was not represented in our PC cases; thus, its interaction with prostate viral infections and cancer could not be evaluated.The contribution of immune and inflammatory responses to the development of cancer has been well recognized in different human tumors [1]. Viral infections may lead to chronic or recurrent inflammation of the prostate and initiate or promote carcinogenesis [2-6]. Infections of the prostate with polyomaviruses (BK, JC, and SV40), human papillomaviruses (HPVs), and members of the herpesvirus family (HHV-8, HCMV, Epstein Barr virus) have been previously described [4,7-11]. Viral products such as the large T antigen of polyomaviruses, or the E6 and E7 proteins of HPVs are able to induce cell transformation and interact with the signaling capacity of the interferon pathway in a synergistic manner [10].The inflammatory etiology of prostate cancer (PC) is supported by the fact that the candidate gene for hereditary PC at the HPC1 locus is RNASEL, which is involved in antiviral and antiproliferative roles of interferons [12-15]. The R462Q variant of the RNASEL gene has been reported to occur in 13% of sporadic cases of
%U http://www.biomedcentral.com/1471-2407/10/326