%0 Journal Article %T Isolated central nervous system relapse of systemic lymphoma (SCNSL): clinical features and outcome of a retrospective analysis %A Patrij %A Katrin %A Reiser %A Marcel %A W£¿tzel %A Luise %A Pels %A Hendrik %J GMS German Medical Science %D 2011 %I German Medical Science, D¨¹sseldorf %X We analyzed clinical outcome of patients with an isolated central nervous system lymphoma (CNSL) relapse after systemic non-Hodgkin¡¯s lymphoma (NHL). All 23 patients with an isolated secondary CNSL (SCNSL) treated at two institutions from 04/2003¨C12/2007 were included into this analysis. At cerebral relapse, 15/23 patients were treated with a regimen consisting of high-dose methotrexate (Bonn protocol). After a median follow-up of 6.5 months (range 1¨C68), 15/23 (65%) patients with SCNSL had relapsed or progressed. HD (high-dose)- methotrexate (MTX) chemotherapy according to the Bonn protocol is effective concerning response rates; however, overall survival of patients with SCNSL seems to be impaired in comparison to relapses in primary CNSL (PCNSL). %K lymphoma %K neoplasia %K chemotherapy %K CNS %K relapse %K methotrexate %U http://www.egms.de/en/journals/gms/2011-9/000134.shtml