%0 Journal Article
%T Comparison of prevalence, viral load, physical status and expression of human papillomavirus-16, -18 and -58 in esophageal and cervical cancer: a case-control study
%A Donghong Zhang
%A Qingying Zhang
%A Li Zhou
%A Leijun Huo
%A Yi Zhang
%A Zhongying Shen
%A Yi Zhu
%J BMC Cancer
%D 2010
%I BioMed Central
%R 10.1186/1471-2407-10-650
%X Seventy cases of ESCC with 60 controls and 39 cases of CSCC with 54 controls collected from patients in Shantou region in China were compared for the distributions of HPV-16, -18 and -58; viral load; and viral integration using real-time PCR assay and HPV-16 expression using immunostaining.The detection rates and viral loads of HR-HPV infection were significantly lower in ESCC than in CSCC (50.0% vs. 79.48%, P = 0.005; 2.55 ¡À 3.19 vs. 361.29 ¡À 441.75, P = 0.002, respectively). The combined integration level of HPV-16, -18 and -58 was slightly lower in ESCC than in CSCC (P = 0.022). HPV-16 expression was detected in 59.26% of ESCC tissue and significantly associated with tumour grade (P = 0.027).High levels of HR-HPV expression and integration may be an indicator of the risk of ESCC, at least for patients in the Shantou region of China. However, a relatively low HPV copy number and infection rate in ESCC is unlikely to play an essential a role in the carcinogenesis of ESCC as in cervical cancer. Factors other than HR-HPV infection may contribute to the carcinogenesis of ESCC.Esophageal squamous cell carcinoma (ESCC) occurs worldwide and has a variable geographic distribution [1]. The Shantou coastal area of eastern Guangdong province, in southern China, has a high incidence of esophageal carcinoma (EC) [2]. Tobacco smoking, alcohol drinking, dietary deficiency, and some local factors, including drinking hot tea and consumption of fermented fish sauce, may be involved in the development of EC in this region [3,4]. However, the etiology of EC is still largely unknown.The association of HPV infection and EC has been reported in the last 30 years, especially in geographic areas with a high incidence of EC. However, unlike cervical carcinoma, with its almost conclusive association with HPV, the causal role of HPV infection in EC remains controversial. This lack of association is due in part to the wide variation in reported infection rates among different studies (from 0%
%U http://www.biomedcentral.com/1471-2407/10/650