%0 Journal Article
%T Polymorphisms of XRCC4 are involved in reduced colorectal cancer risk in Chinese schizophrenia patients
%A Yang Wang
%A Lei Wang
%A Xingwang Li
%A Baocheng Liu
%A Qingzhu Zhao
%A Peng Chen
%A Ti Wang
%A Tao Li
%A Jue Ji
%A Fengping Yang
%A Quan Wang
%A Jinfen Wang
%A Yanzeng Xiao
%A Yifeng Xu
%A Guoyin Feng
%A Zhihai Peng
%A Lin He
%A Guang He
%J BMC Cancer
%D 2010
%I BioMed Central
%R 10.1186/1471-2407-10-523
%X To examine the genetic association between colorectal cancer and schizophrenia, we analyzed five SNPs (rs6452526, rs2662238, rs963248, rs35268, rs2386275) covering ~205.7 kb in the region of XRCC4.We observed that two of the five genetic polymorphisms showed statistically significant differences between 312 colorectal cancer subjects without schizophrenia and 270 schizophrenia subjects (rs6452536, p = 0.004, OR 0.61, 95% CI 0.44-0.86; rs35268, p = 0.028, OR 1.54, 95% CI 1.05-2.26). Moreover, the haplotype which combined all five markers was the most significant, giving a global p = 0.0005.Our data firstly indicate that XRCC4 may be a potential protective gene towards schizophrenia, conferring reduced susceptibility to colorectal cancer in the Han Chinese population.The correlation between schizophrenia and cancer has been investigated for over a century, but the research on this epidemiological puzzle has produced contradictory findings [1,2]. According to recent studies, reduced risk and incidence for cancer were found to be associated with schizophrenia [3-5]. The explanations proposed for this finding have included genetic factors, neuroleptic medication, and environmental aspects [5-7]. The genetic basis of this lower risk has been ascribed to specific protective mechanism against cancer found in schizophrenia patients [7]. But until now p53 is the only gene to have been reported as being involved in this protective mechanism [8]. Recently, Park et al. [8] made a genetic association analysis of SNPs in the p53 gene between 104 lung cancer patients and 179 schizophrenia patients, and the results indicated that the p53 polymorphisms might be a genetic marker for lower susceptibility to lung cancer in schizophrenia patients.The X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4) gene is located on chromosome 5q14.2, which showed loss of heterozygosity (LOH) in sporadic colorectal cancer (Ratio 37.7%), and high ratio LOH indicates the pres
%U http://www.biomedcentral.com/1471-2407/10/523