%0 Journal Article
%T Opposing function of MYBBP1A in proliferation and migration of head and neck squamous cell carcinoma cells
%A Gustavo A AcuŁża Sanhueza
%A Leonie Faller
%A Babitha George
%A Jennifer Koffler
%A Vinko Misetic
%A Christa Flechtenmacher
%A Gerhard Dyckhoff
%A Peter P Plinkert
%A Peter Angel
%A Christian Simon
%A Jochen Hess
%J BMC Cancer
%D 2012
%I BioMed Central
%R 10.1186/1471-2407-12-72
%X We applied global gene expression profiling with samples derived from a recently established mouse model for oral cancer recurrence and identified a list of genes with differential expression between primary and recurrent tumors.One differentially expressed gene codes for Myb-binding protein 1a (MYBBP1A), which is known as a transcriptional co-regulator that physically interacts with nuclear transcription factors, such as NF¦ĘB and p53. We confirmed significantly reduced MYBBP1A protein levels on tissue sections of recurrent mouse tumors compared to primary tumors by immunohistochemistry, and found aberrant MYBBP1A protein levels also in tumor samples of HNSCC patients. Interestingly, silencing of MYBBP1A expression in murine SCC7 and in human HNSCC cell lines elicited increased migration but decreased cell growth.We provide experimental evidence that MYBBP1A is an important molecular switch in the regulation of tumor cell proliferation versus migration in HNSCC and it will be a major challenge for the future to proof the concept whether regulation MYBBP1A expression and/or function could serve as a novel option for anti-cancer therapy.Head and neck squamous cell carcinoma (HNSCC) is the most common type of head and neck cancer primarily affecting the mucosa of the upper aero digestive tract [1]. Tobacco and alcohol consumption are the main risk factors for HNSCC and have a multiplicative combined effect [1]. In recent years, there has been an increase in the annual incidence of HPV-related HNSCC, suggesting that a subset of HNSCC is a sexual transmitted disease with distinct pathogenesis and clinical features [2].In spite of considerable advances in diagnosis, treatment and our understanding of the molecular alterations that occur in the pathogenesis of HNSCC, a high rate of local recurrences and distant metastasis aggravates the clinical situation, and the 5-year survival rate of patients with an advanced disease has remained at approximately 50% [3,4]. Therefore,
%U http://www.biomedcentral.com/1471-2407/12/72