%0 Journal Article
%T Neck control after definitive radiochemotherapy without planned neck dissection in node-positive head and neck cancers
%A Na Young Jang
%A Keun-Wook Lee
%A Soon-Hyun Ahn
%A Jae-Sung Kim
%A In-Ah Kim
%J BMC Cancer
%D 2012
%I BioMed Central
%R 10.1186/1471-2407-12-59
%X We retrospectively reviewed medical records of fifty patients with node-positive head and neck cancer who received definitive radiochemotherapy. Twelve patients subsequently underwent neck dissection for suspicious recurrent or persistent disease. A median dose of 70 Gy (range 60-70.6) was delivered to involved nodes. Response evaluation was performed at a median of 5 weeks after completion of radiotherapy.Neck failure was observed in 11 patients and the 3-year regional control (RC) rate was 77.1%. Neck dissection was performed in 10 of the 11 patients; seven of these cases were successfully salvaged, and the ultimate rate of neck control was 92%. The remaining two patients who received neck dissection had negative pathologic results. On univariate analysis, initial nodal size > 2 cm, a less-than-complete response at the primary site, post-radiotherapy nodal size > 1.5 cm, and post-radiotherapy nodal necrosis were associated with RC. On multivariate analysis, less-than-complete primary site response and post-radiotherapy nodal necrosis were identified as independent prognostic factors for RC.The neck failure rate after definitive radiochemotherapy without planned neck dissection was 22%. Two-thirds of these were successfully salvaged with neck dissection and the ultimate neck control rate was 92%. Our results suggest that planned neck dissection might not be necessary in patients with complete response of primary site, no evidence of residual lesion > 1.5 cm, or no necrotic lymph nodes at the 1-2 months follow-up evaluation after radiotherapy.Radiotherapy combined with systemic therapy results in increased locoregional control with organ preservation in locally advanced head and neck cancers [1-4]. However, there has been controversy over neck treatment after definitive radiochemotherapy; specifically, whether to perform a subsequent "planned" neck dissection (regardless of nodal response) or only "salvage" neck dissection for persistent or recurrent disease [5]. Th
%U http://www.biomedcentral.com/1471-2407/12/59