%0 Journal Article
%T Estimation of the epidemiological burden of human papillomavirus-related cancers and non-malignant diseases in men in Europe: a review
%A Susanne Hartwig
%A Stina Syrj£¿nen
%A G¨¦raldine Dominiak-Felden
%A Maria Brotons
%A Xavier Castellsagu¨¦
%J BMC Cancer
%D 2012
%I BioMed Central
%R 10.1186/1471-2407-12-30
%X The annual number of new HPV-related cancers in men in Europe was estimated using Eurostat population data and applying cancer incidence rates published by the International Agency for Research on Cancer. The number of cancer cases attributable to HPV, and specifically to HPV16/18, was calculated based on the most relevant prevalence estimates. The annual number of new cases of genital warts was calculated from the most robust European studies; and latest HPV6/11 prevalence estimates were then applied. A literature review was also performed to retrieve exhaustive data on HPV infection at all anatomical sites under study, as well as incidence and prevalence of external genital warts, recurrent respiratory papillomatosis and HPV-related cancer trends in men in Europe.A total of 72, 694 new cancer cases at HPV-related anatomical sites were estimated to occur each year in men in Europe. 17,403 of these cancer cases could be attributable to HPV, with 15,497 of them specifically attributable to HPV16/18. In addition, between 286,682 and 325,722 new cases of genital warts attributable to HPV6/11were estimated to occur annually in men in Europe.The overall estimated epidemiological burden of HPV-related cancers and non-malignant diseases is high in men in Europe. Approximately 30% of all new cancer cases attributable to HPV16/18 that occur yearly in Europe were estimated to occur in men. As in women, the vast majority of HPV-positive cancer in men is related to HPV16/18, while almost all HPV-related non-malignant diseases are due to HPV6/11. A substantial number of these malignant and non-malignant diseases may potentially be prevented by quadrivalent HPV vaccination.Human papillomavirus (HPV) has been established as a necessary cause of cervical cancer. Around 50% of women become infected with HPV by age 20-30 years [1] and persistent infection can lead to the development of malignant and non-malignant diseases. Indeed, the role of HPV in cervical cancer, in premalignant l
%K HPV
%K Epidemiology
%K Cancer
%K Genital warts
%K Condylomata acuminata
%K Men
%K Europe
%U http://www.biomedcentral.com/1471-2407/12/30