%0 Journal Article
%T Interleukin-10-819 promoter polymorphism in association with gastric cancer risk
%A Huiping Xue
%A Bing Lin
%A Jianfu An
%A Yuyuan Zhu
%A Gang Huang
%J BMC Cancer
%D 2012
%I BioMed Central
%R 10.1186/1471-2407-12-102
%X Each initially included article was scored for quality appraisal. Desirable data were extracted and registered into databases. 11 studies were ultimately eligible for the meta-analysis of IL-10 -819 T/C SNP. We adopted the most probably appropriate genetic model (recessive model). Potential sources of heterogeneity were sought out via subgroup and sensitivity analyses, and publication biases were estimated.IL-10 -819 TT genotype is associated with the overall reduced gastric cancer risk among Asians and even apparently observed among high quality subgroup Asians. IL-10-819 TT genotype is not statistically associated with the overall reduced gastric cancer susceptibility in persons with H. pylori infection compared with controls without H. pylori infection. IL-10 -819 TT genotype is reversely associated with diffuse-subtype risk but not in intestinal-subtype risk. IL-10 -819 TT genotype is not reversely associated with non-cardia or cardia subtype gastric cancer susceptibility.IL-10 -819 TT genotype seems to be more protective from gastric cancer in Asians. Whether IL-10 -819 TT genotype may be protective from gastric cancer susceptibility in persons infected with H. pylori or in diffuse-subtype cancer needs further exploring in the future well-designed high quality studies among different ethnicity populations. Direct sequencing should be more used in the future.Nowadays, worldwide gastric cancer incidence has decreased but its mortality still ranks second [1-3]. In Asia [4], especially China [5], gastric cancer constitutes the top lethal malignancy. As is widely known, infectious, dietary, environmental, and genetic factors are implicated in gastric carcinogenesis, but only a minority of persons exposed to risk factors such as Helicobacter pylori (H. pylori) infection ultimately develop gastric cancer [6], which implies that host genetic susceptibility plays an important role in developing gastric cancer [7-9]. Such various susceptibilities could be explained, in p
%K Interleukin 10
%K Gene
%K Single nucleotide polymorphism
%K Association
%K Gastric cancer
%U http://www.biomedcentral.com/1471-2407/12/102