%0 Journal Article
%T Isometric muscle training of the spine musculature in patients with spinal bony metastases under radiation therapy
%A Harald Rief
%A Alexandra D Jensen
%A Thomas Bruckner
%A Klaus Herfarth
%A Jščrgen Debus
%J BMC Cancer
%D 2011
%I BioMed Central
%R 10.1186/1471-2407-11-482
%X This study is a prospective, randomized, monocentre, controlled explorative intervention study in the parallel-group design to determine the multidimensional effects of a course of exercises at first under physiotherapeutic instruction and subsequently performed by the patients independently for strengthening the paravertebral muscles of patients with metastases of the vertebral column parallel to their percutaneous radiotherapy. On the days of radiation treatment the patients in the control group shall be given physical treatment in the form of respiratory therapy and the so-called "hot roll". The patients will be randomized into one of the two groups: differentiated muscle training or physiotherapy with thirty patients in each group.The aim of the study is to evaluate the feasibility of the training programme described here. Progression-free and fracture-free survival, improved response to radiotherapy by means of bone density, and clinical parameters such as pain, quality of life, and fatigue constitute secondary study objectives.ClinicalTrials.gov: NCT01409720Osseous metastatic involvement of the spinal column affects many patients with a primary tumour disease of all entities. In many cases this involvement is indicative of a progressed stage of a primary malignant disease. 70 percent of all patients who die of the sequelae of the tumour disease exhibit bone metastases [1]. 80 percent of all osseous metastases originate from mammary, prostatic, bronchial, renal-cell, or thyroid carcinomas [2]. In men, the primary tumour in 60 percent of all cases is a carcinoma of the prostate [3], among women, it is in 70 percent of the cases a mammary carcinoma. 30 percent of all metastases of the skeletal system and ten percent of all primary bone tumours are found in the spinal column. The former are located in the lumbar (52%), thoracic (36%) and cervical column (12%) [4]. The consequences are pain both at rest and under exertion, impairments in going about day-to-day acti
%U http://www.biomedcentral.com/1471-2407/11/482