%0 Journal Article
%T The value of prognostic factors for uterine cervical cancer patients treated with irradiation alone
%A R¨±ta Grigien£¿
%A Konstantinas P Valuckas
%A Eduardas Aleknavi£¿ius
%A Juozas Kurtinaitis
%A Simona R Letautien£¿
%J BMC Cancer
%D 2007
%I BioMed Central
%R 10.1186/1471-2407-7-234
%X 162 patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIA-IIIB cervical carcinoma treated with irradiation were analysed. Univariate and multivariate analyses using the Cox regression model were performed to determine statistical significance of some tumor-related factors.The Hb level before treatment showed significant influence on overall survival (p = 0.001), desease free survival (p = 0.040) and local control (p = 0.038). The lymph node status (>10 mm) assessed on CT had impact on overall survival (p = 0,030) and local control (p = 0,036). The dose at point A had impact on disease free survival (p = 0,028) and local control (p = 0,021) and the radiotherapy duration had showed significant influence on overall survival (p = 0,045), disease free survival (p = 0,006) and local control (p = 0,033).Anemia is a significant and independent prognostic factor of overall survival, disease-free survival and local control in cervical cancer patients treated with irradiation. The size of lymph nodes in CT is an independent prognostic factor for overall survival and local control in cervical cancer patients. The size of cervix uteri evaluated by CT has no prognostic significance in cervical cancer patients treated with radiotherapy. The prognostic value of FIGO stage of cervical cancer is influenced by other factors, analyzed in this study and is not an independent prognostic factor.In 2004, 569 new cases of cervical cancer were diagnosed in Lithuania. This number is higher (by about 100 cases) than that observed in 2003. The lifetime risk of cervical cancer in Lithuania is 1 of 65 women. Most often cervical cancer develops in women aged 30 to 59 years, i.e. when they are most able-bodied. In 33% of patients stage I and in 21% ¨C stage II were diagnosed. Advanced cervical cancer (stages III and IV) was diagnosed in 46% of patients [1]. Radiotherapy was usually used in stages II-IV cervical cancer. About 60% of patients with cervical cancer in Lith
%U http://www.biomedcentral.com/1471-2407/7/234