%0 Journal Article
%T Expression of human Piwi-like genes is associated with prognosis for soft tissue sarcoma patients
%A Thomas Greither
%A Franziska Koser
%A Matthias Kappler
%A Matthias Bache
%A Christine Lautenschl£¿ger
%A Steffen G£¿bel
%A Hans-J¨¹rgen Holzhausen
%A Sven Wach
%A Peter W¨¹rl
%A Helge Taubert
%J BMC Cancer
%D 2012
%I BioMed Central
%R 10.1186/1471-2407-12-272
%X We measured the expression of Piwi-like mRNAs (Piwi-like 2¨C4) in 125 soft tissue sarcoma (STS) samples by qPCRs. Statistical tests were applied to study the correlation of expression levels with tumor-specific survival for STS patients.In multivariate Cox¡¯s regression analyses, we showed that low Piwi-like 2 and Piwi-like 4 mRNA expression were significantly associated with a worse prognosis (RR£¿=£¿1.87; p£¿=£¿0.032 and RR£¿=£¿1.82; p£¿=£¿0.039). Low expression of both genes was associated with a 2.58-fold increased risk of tumor-related death (p£¿=£¿0.01). Piwi-like 4 and combined Piwi-like 2 and 4 mRNA levels correlated significantly with prognosis (RR£¿=£¿3.53; p£¿=£¿0.002 and RR£¿=£¿5.23; p£¿=£¿0.004) only for female but not for male patients. However, combined low Piwi-like 2 and 3 transcript levels were associated with worse survival (RR£¿=£¿5.90; p£¿=£¿0.02) for male patients.In this study, we identified a significant association between the expression of Piwi-like 2 and 4 mRNAs and the tumor-specific survival of soft tissue sarcoma patients. Furthermore, a connection between sex and the impact of Piwi-like mRNA expressions on STS patients¡¯ prognosis was shown for the first time.
%U http://www.biomedcentral.com/1471-2407/12/272/abstract