%0 Journal Article
%T Hypovitaminosis D and prevalent asymptomatic vertebral fractures in Moroccan postmenopausal women
%A Abdellah El Maghraoui
%A Zhor Ouzzif
%A Aziza Mounach
%A Asmaa Rezqi
%A Lahsen Achemlal
%A Ahmed Bezza
%A Saida Tellal
%A Mohamed Dehhaoui
%A Imad Ghozlani
%J BMC Women's Health
%D 2012
%I BioMed Central
%R 10.1186/1472-6874-12-11
%X To determine serum vitamin D status and to assess the association of vitamin D status with bone mineral density (BMD) and asymptomatic VFs prevalence using vertebral fracture assessment (VFA) in a cohort of Moroccan menopausal women.from June to September 2010, 178 menopausal women 50£¿years old and over were enrolled in this cross-sectional study. The mean£¿¡À£¿SD (range) age, weight, height and BMI were 58.8£¿¡À£¿8.2 (50 to 79) years, 73.2£¿¡À£¿13.8 (35 to 119) Kgs, 1.56£¿¡À£¿0.06 (1.43 ¨C 1.79) m and 29.8£¿¡À£¿5.9 (17.5 ¨C 49.8) kg/m2, respectively. VFA images and scans of the lumbar spine and proximal femur were obtained using a GE Healthcare Lunar Prodigy densitometer. VFs were defined using a combination of Genant semiquantitative approach and morphometry. Serum levels of 25-hydroxyvitamin D (25(OH)D) were measured.Among the 178 women, 45 (25.2%) had densitometric osteoporosis, and on VFA, VFs (grade 2 or 3) were detected in 20.2% while grade 1 were identified in 33.1%. The mean values of serum levels of 25(OH)D were 15.8£¿¡À£¿11.6£¿ng/ml (range: 3.0 ¨C 49.1) with 152 patients (85.3%) having levels <30£¿ng/ml (insufficiency) and 92 (51.6%) <10£¿ng/ml (deficiency). Stepwise regression analysis showed that presence of VFs was independently related to age, 25(OH)D and densitometric osteoporosis.our study shows that advanced age, hypovitaminosis D and osteoporosis are independent risk factors for asymptomatic VFs in Moroccan postmenopausal women.Osteoporosis and low-trauma fractures in elderly people are a substantial and increasing burden of ill health worldwide and the rates of hip and other fractures are rapidly increasing in developing countries [1]. Vitamin D status has for long been recognized as an important factor for bone health and its contribution to fracture risk has recently received increased attention. It is demonstrated that hypovitaminosis D is associated to accentuated bone loss, leading to an increased risk of osteoporotic fractures. Moreover, new data suggest that its
%K Osteoporosis
%K Vertebral fractures
%K VFA
%K DXA
%K 25(OH) vitamin D
%U http://www.biomedcentral.com/1472-6874/12/11