%0 Journal Article
%T Sex differences in HDL ApoC-III in American Indian youth
%A Blackett Piers R
%A Khan Sohail
%A Wang Wenyu
%A Alaupovic Petar
%J Biology of Sex Differences
%D 2012
%I BioMed Central
%R 10.1186/2042-6410-3-18
%X Background Since American Indians are predisposed to type 2 diabetes (DM2) and associated cardiovascular risk, Cherokee boys and girls (n = 917) were studied to determine whether BMI Z (body mass index Z score) is associated with the apoC-III (apolipoprotein C-III) content of HDL (high density lipoprotein), a previously reported predictor of DM2. Methods An ad hoc cross-sectional analysis was conducted on a previously studied cohort. Participants were grouped by gender-specific age groups (5 to 9, 10 to 14 and 15 to 19 years). ApoA-I (apolipoprotein A-I) and HDL apoC-III were assayed by electroimmunoassay. ApoC-III was measured in whole plasma, and in HDL to determine the molar proportion to apoA-I. General linear models were used to assess association. Results The HDL apoC-III to apoA-I molar ratio increased by BMI Z quartile in girls aged 10¨C14 years (p < 0.05 for linear trend, p < 0.05 for difference in BMI Z quartile IV vs. I to III) and aged 15¨C19 years (p < 0.05 for trend). In boys the increase by BMI Z occurred only at ages 15¨C19 years (p < 0.01 for trend and for quartile difference). Conclusions ApoC-III showed an obesity-related increase relative to apoA-I during adolescence beginning in girls aged 10 to 14 years and in boys aged 15 to 19 years. The earlier changes in girls may alter HDL¡¯s protective properties on the ¦Â-cell and contribute to their increased risk for DM2.
%K Gender
%K HDL
%K ApoC-III
%K Children
%K Adolescents
%U http://www.bsd-journal.com/content/3/1/18