%0 Journal Article %T From pharmaceutical standardizing to clinical research: 20 years of experience with fifty-millesimal potencies %A Ubiratan Cardinalli Adler %A Amarilys de Toledo Cesar %A Maristela Schiabel Adler %A Ana Elisa Padula %J International Journal of High Dilution Research %D 2009 %I Universidade Estadual Paulista %X Background: 20 years ago we began to standardize the procedures of preparation and use of fifty-millesimal dilutions (LM or Q) according to indications in the 6th edition of Hahnemann ¡éa a ¡és Organon. Aim: to describe the main stages in standardization as well as our teaching and research experience on Organon 6th edition. Results: with the use of standardized LM dilutions we observed a lower incidence of homeopathic aggravation than with our earlier experience with non standardized preparations. Organon.modus, a clinical-pharmaceutical protocol derived from the standardization was adequate for the teaching of homeopathy at Faculty of Medicine of Jundiai (S ¡êo Paulo), the first Brazilian medical school with a graduate course on homeopathy. A randomized double-blind trial comparing individualized homeopathic medicines prescribed in LM dilutions and fluoxetine showed the former not be inferior to the latter in the treatment of moderate-to-severe depression. Conclusion: protocol Organon.modus showed to be adequate to graduate-level teaching of homeopathy and efficient in a controlled clinical trials, favoring its use as common denominator between the art of healing and medical science. %K Homeopathy %K LM (Q) dilutions %K Organon 6th edition %K clinical-pharmaceutical protocol %K medical education %K randomized double-blind clinical trial %U http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/view/367