%0 Journal Article
%T Characterization of the association between 8q24 and colon cancer: gene-environment exploration and meta-analysis
%A Carolyn M Hutter
%A Martha L Slattery
%A David J Duggan
%A Jill Muehling
%A Karen Curtin
%A Li Hsu
%A Shirley AA Beresford
%A Aleksandar Rajkovic
%A Gloria E Sarto
%A James R Marshall
%A Nazik Hammad
%A Robert Wallace
%A Karen W Makar
%A Ross L Prentice
%A Bette J Caan
%A John D Potter
%A Ulrike Peters
%J BMC Cancer
%D 2010
%I BioMed Central
%R 10.1186/1471-2407-10-670
%X We examined 11 SNP markers in the 8q24 region between 128.47 and 128.54 Mb, using a total of 1,987 colon cases and 2,339 controls who self-reported as white from two independent, well-characterized study populations. Analysis was performed separately within each study, and combined using random effects meta-analysis. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) and to test for effect modification by known colon cancer risk factors. We also performed a meta-analysis combining our results with previous studies.We observed evidence of association for four SNPs in low to high linkage disequilibrium (r2 ranging from 0.18 to 0.93) localized in a 16.2 kb region defined by rs10505477 and rs1056368. The combined results for our two studies of colon cancer showed an OR of 1.10 (95% CI: 1.01-1.20, Ptrend = 0.023), and a meta-analysis of our results with previously reported studies of colon and colorectal cancer strongly support the association for this SNP (combined OR for rs6983267 = 1.21, 95% CI: 1.18-1.24, p = 5.5 กม 10-44). We did not observe any notable evidence of effect modification by known colon cancer risk factors, and risk did not differ significantly by tumor site or stage.Our study confirms the association between polymorphisms on chromosome 8q24 and colon cancer risk and suggests that the susceptibility locus in region 8q24 is not strongly modified by various lifestyle, environmental, and demographic risk factors for colon cancer.Colorectal cancer is the third leading cause of cancer and cancer death for both men and women in the United States [1]. At least 20%, and perhaps as much as one-third, of colorectal cancer is attributable to inherited factors [2]. High-penetrance mutations, such as those of the adenomatous polyposis coli gene (APC) and DNA mismatch-repair genes, account for < 5% of the cases and it is expected that a large proportion of the inherited susceptibility is likely to be explained by numerous
%U http://www.biomedcentral.com/1471-2407/10/670