%0 Journal Article
%T Molecular subtype analysis determines the association of advanced breast cancer in Egypt with favorable biology
%A Bodour Salhia
%A Coya Tapia
%A Elia A Ishak
%A Salwa Gaber
%A Bree Berghuis
%A Khateeb H Hussain
%A Rachelle A DuQuette
%A James Resau
%A John Carpten
%J BMC Women's Health
%D 2011
%I BioMed Central
%R 10.1186/1472-6874-11-44
%X To determine molecular subtypes we characterized over 200 tumor specimens obtained from Egypt by performing ER, PR, Her2, CK5/6, EGFR and Ki67 immunohistochemistry.Our study demonstrated that the Luminal A subtype, associated with favorable prognosis, was found in nearly 45% of cases examined. However, the basal-like subtype, associated with poor prognosis, was found in 11% of cases. These findings are in sharp contrast to other parts of Africa in which the basal-like subtype is over-represented.Egyptians appear to have favorable underlying biology, albeit having advanced disease at diagnosis. These data suggest that Egyptians would largely profit from early detection of their disease. Intervention at the public health level, including education on the benefits of early detection is necessary and would likely have tremendous impact on breast cancer outcome in Egypt.The World Health Organization has ranked breast cancer as the most common type of cancer among women world-wide [1]. The incidence rates of breast cancer vary worldwide, with higher rates in North America, Northern and Western Europe; intermediate rates in South America and Southern Europe; and lower rates in Africa and Asia. According to GLOBOCAN 2008 [1] breast cancer accounts for 38% of all new cancer cases among women living in Egypt. The age-standardized rate (ASR) for breast cancer incidence in Egypt is 37.3 compared to 76 in the United States. Although incidence remains significantly lower than in highly developed countries, rates are steadily increasing [2,3]. Mortality rates in Egypt are worse (20.1 per 100 000) then they are in the United States (14.7 per 100 000), and is the leading cause of cancer-related deaths.There is evidence that the global burden of cancer is shifting gradually to the developing world, and may equally affect or even surpass that of Western societies within the foreseeable future [1]. Despite this shift, breast cancer research in Africa comprises less than 1% of the liter
%K Egypt
%K Breast Cancer subtypes
%K ethnicity
%K early detection
%K Africa
%U http://www.biomedcentral.com/1472-6874/11/44