%0 Journal Article
%T ¦Ä-ALA-D activity is a reliable marker for oxidative stress in bone marrow transplant patients
%A Thissiane L Gon£¿alves
%A Dalila M Benvegn¨²
%A Gabriela Bonfanti
%A Andressa V Frediani
%A Jo£¿o Rocha
%J BMC Cancer
%D 2009
%I BioMed Central
%R 10.1186/1471-2407-9-138
%X Lipid peroxidation, vitamin C and thiol group levels as well as catalase, superoxide dismutase and ¦Ä-ALA-D activity were determined in 37 healthy controls, 13 patients undergoing autologous peripheral blood stem cell transplantation and 24 patients undergoing allogeneic BMT.We found that patients presented signs of oxidative stress before they were submitted to BMT, during CR and up to 20 days after BMT. There was a decrease in enzymatic and non enzymatic antioxidant defenses, in ¦Ä-ALA-D activity, and an increase in lipoperoxidation in the blood of both patient groups.This study has indicated that autologous and allogeneic BMT are associated with oxidative stress. Moreover, blood ¦Ä-ALA-D activity seems to be an additional biomarker of oxidative stress in BMT patients.Bone marrow transplantation (BMT) is a therapeutic method used in various malignant, hematologic, immunologic, and genetic diseases [1]. Allogeneic transplantation involves the transfer of marrow from a donor to another person, and one of the main problems in this procedure is the graft-versus-host disease [2]. Allogeneic transplantations are preferred for patients with leukemias or myeloproliferative diseases [3] whereas autologous transplantations are generally performed in patients with multiple myeloma (MM) or lymphoma [4,5]. Autologous BMT involves the use of the patient's own marrow to reestablish hematopoietic cell function after the administration of high-dose chemotherapy. In this case the stem cells can be taken from the patient's bone marrow or peripheral blood [2]. Peripheral blood stem cell transplantation (PBSCT) with collection by apheresis has replaced bone marrow as a source of hematopoietic stem cells for autologous transplantation, because this type of collection results in a more rapid hematopoietic recovery [5,6]. In contrast, in allogeneic transplantation, bone marrow continues to be the principal source of cells [7].Unlike allogeneic transplantation, autologous transplantation is
%U http://www.biomedcentral.com/1471-2407/9/138