%0 Journal Article
%T Maternal consumption of canola oil suppressed mammary gland tumorigenesis in C3(1) TAg mice offspring
%A Gabriela Ion
%A Juliana A Akinsete
%A W Elaine Hardman
%J BMC Cancer
%D 2010
%I BioMed Central
%R 10.1186/1471-2407-10-81
%X Female SV 129 mice were divided into two groups and placed on diets containing either 10% w/w corn oil (which is 50% n-6 PUFA, control diet) or 10% w/w canola oil (which is 20% n-6 PUFA, 10% n-3 PUFA, test diet). After two weeks on the diets the females were bred with homozygous C3(1) TAg transgenic mice. Mother mice consumed the assigned diet throughout gestation and nursing of the offspring. After weaning, all female offspring were maintained on the control diet.Compared to offspring of mothers fed the corn oil diet (CO/CO group), offspring of mothers fed the canola oil diet (CA/CO group) had significantly fewer mammary glands with tumors throughout the experiment. At 130 days of age, the CA/CO group had significantly fewer tumors per mouse (multiplicity); the tumor incidence (fraction of mice with any tumor) and the total tumor weight (per mouse that developed tumor) was less than one half that of the CO/CO group. At 170 days of age, the total tumor weight per mouse was significantly less in the CA/CO group and if a tumor developed the rate of tumor growth rate was half that of CO/CO group. These results indicate that maternal consumption of canola oil was associated with delayed appearance of mammary gland tumors and slowed growth of the tumors that developed.Substituting canola oil for corn oil is an easy dietary change for people to make; such a change to the maternal diet may decrease risk for breast cancer in the daughter.It has been shown that diets that contain high amounts of omega 6 polyunsaturated fatty acids (PUFA) increase the growth rates of cancers [1] whereas omega 3 PUFA have been shown to reduce cancer growth rates [2] and have been suggested as cancer preventive agents [3]. The type of fat consumed by the mother during pregnancy and nursing of the offspring has also been shown to influence mammary gland cancer risk in the offspring. A maternal diet that contained a high (versus low) amount of omega 6 fatty acids increased the risk for mammary gl
%U http://www.biomedcentral.com/1471-2407/10/81