%0 Journal Article
%T A Clinical phase I/II trial to investigate preoperative dose-escalated intensity-modulated radiation therapy (IMRT) and intraoperative radiation therapy (IORT) in patients with retroperitoneal soft tissue sarcoma
%A Falk FF Roeder
%A Daniela Schulz-Ertner
%A Anna V Nikoghosyan
%A Peter E Huber
%A Lutz Edler
%A Gregor Habl
%A Robert Krempien
%A Susanne Oertel
%A Ladan Saleh-Ebrahimi
%A Frank W Hensley
%A Markus W Buechler
%A Juergen Debus
%A Moritz Koch
%A Juergen Weitz
%A Marc Bischof
%J BMC Cancer
%D 2012
%I BioMed Central
%R 10.1186/1471-2407-12-287
%X The trial is a prospective, one armed, single center phase I/II study investigating a combination of neoadjuvant dose-escalated IMRT (50¨C56£żGy) followed by surgery and IORT (10¨C12£żGy) in patients with at least marginally resectable RSTS. The primary objective is the local control rate after five years. Secondary endpoints are progression-free and overall survival, acute and late toxicity, surgical resectability and patterns of failure. The aim of accrual is 37 patients in the per-protocol population.The present study evaluates combined neoadjuvant dose-escalated IMRT followed by surgery and IORT concerning its value for improved local control without markedly increased toxicity.NCT01566123
%U http://www.biomedcentral.com/1471-2407/12/287/abstract