%0 Journal Article
%T Molecular Mechanisms of Hemoglobin F Induction
%A Majid Farshdousti Hagh
%A Ali Dehghani Fard
%A Najmaldin Saki
%A Mohammad Shahjahani
%J International Journal of Hematology-Oncology and Stem Cell Research
%D 2011
%I 
%X Hemoglobin F (HbF, ¦Á2¦Ã2) is a major contributor to the clinical heterogeneity and ameliorating agent observed in patients with the ¦Â-globin disorders including ¦Â-thalassemia and sickle cell disease (SCD). During fetal life, HbF is the major hemoglobin but is largely substituted by adult hemoglobin (HbA, ¦Á2¦Â2) following a globin expression switch after birth. Increased ¦Ã-globin expression can reduce the clinical severity of ¦Â-thalassemia and SCD. Therefore, increase in HbF production has served as a longstanding goal. The progression of target-based therapeutics has been confused by limited comprehension of molecular mechanisms of gamma-globin gene expression. However, recent discoveries of regulators of HbF level represent a major development and provide new opportunities in employing novel rational therapeutic strategies. In this review, molecular mechanisms of hemoglobin F induction will be discussed.
%K Hemoglobin F
%K ¦Â-thalassemia
%K Expression
%K Induction
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/20851.pdf&manuscript_id=20851