%0 Journal Article
%T Nitric Oxide: Oxygen Radical Interactions in Atherosclerosis
%A HOMERO RUBBO
%A CARLOS BATTHYANY
%A RAFAEL RADI
%J Biological Research
%D 2000
%I Sociedad de Biolog¨ªa de Chile
%X Atherosclerosis is one of the most common diseases and the principal cause of death in western civilization. The pathogenesis of this disease can be explained on the basis of the ¡®oxidative-modification hypothesis,¡¯ which proposes that low-density lipoprotein (LDL) oxidation represents a key early event. Nitric oxide (.NO) regulates critical lipid membrane and lipoprotein oxidation events by a) contributing to the formation of more potent secondary oxidants from superoxide (i.e.: peroxynitrite), and b) its antioxidant properties through termination reactions with lipid radicals to possibly less reactive secondary nitrogen-containing products (LONO, LOONO). Relative rates of production and steady state concentrations of superoxide and .NO and cellular sites of production will profoundly influence the expression of differential oxidant injury-enhancing and protective effects of .NO. Full understanding of the physiological roles of .NO, coupled with detailed insight into .NO regulation of oxygen radical-dependent reactions, will yield a more rational basis for intervention strategies directed toward oxidant-dependent atherogenic processes
%K antioxidants
%K free radicals
%K lipid oxidation
%K low density lipoprotein oxidation
%K nitric oxide
%K peroxynitrite
%U http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200017