%0 Journal Article
%T Peste des Petits Ruminants (PPR) in Ethiopia: Analysis of a national serological survey
%A Agn豕s Waret-Szkuta
%A Franˋois Roger
%A David Chavernac
%A Laikemariam Yigezu
%A Genevi豕ve Libeau
%A Dirk U Pfeiffer
%A Javier Guiti芍n
%J BMC Veterinary Research
%D 2008
%I BioMed Central
%R 10.1186/1746-6148-4-34
%X We explored the spatial distribution of PPR in Ethiopia and we investigated risk factors for positive serological status. Intracluster correlation coefficients (老), were calculated for 43 wereda (administrative units).Seroprevalence was very heterogeneous across regions and even more across wereda, with prevalence estimates ranging from 0% to 52.5%. Two groups of weredas could be distinguished on the basis of the estimated 老: a group with very low 老 (老 < 0.12) and a group with very high 老 (老 > 0.37).The results indicate that PPRV circulation has been very heterogeneous, the values for the 老 may reflect the endemic or epidemic presence of the virus or the various degrees of mixing of animals in the different areas and production systems. Age appears as a risk factor for seropositive status, the linear effect seeming to confirm in the field that PPRV is highly immunogenic. Our estimates of intracluster correlation may prove useful in the design of serosurveys in other countries where PPR is of importance.Peste des Petits Ruminants (PPR) is a severe and highly infectious viral disease of small ruminants. The PPR virus (PPRV) belongs to the genus Morbillivirus in the family Paramyxoviridae. It is closely related to the rinderpest virus of bovines and buffaloes, distemper virus of dogs and other wild carnivores, human measles virus and Morbilliviruses of marine mammals [1-4]. In small ruminants, infection by PPRV is characterized by sudden depression, fever, nasal and ocular discharge, diarrhoea and occasionally death. Morbidity in the range of 10 to 80% and mortality proportions from 0 to 90% have been reported. The wide range of reported values is likely to be influenced by differences between species (sheep or goats), production systems and levels of natural or acquired immunity [5-10].PPR was first described in West Africa in 1942 [11]. Nowadays the disease is recognized as responsible for mortality and morbidity across most of the sub-Saharan African countries situa
%U http://www.biomedcentral.com/1746-6148/4/34