%0 Journal Article
%T The effect of moxidectin 0,1% vs ivermectin 0,08% on milk production in sheep naturally infected by gastrointestinal nematodes
%A Giuseppe Cringoli
%A Vincenzo Veneziano
%A Laura Mezzino
%A Mariaelena Morgoglione
%A Saverio Pennacchio
%A Laura Rinaldi
%A Vincenzo Salamina
%J BMC Veterinary Research
%D 2009
%I BioMed Central
%R 10.1186/1746-6148-5-41
%X The treatment with moxidectin was highly effective (> 98%) from day 7 until day 75, and effective (90-98%) until day 105. The treatment with ivermectin was highly effective (> 98%) from day 7 until day 14, effective (90-98%) at day 28 and moderately effective (80-89%) on day 45. The milk productions in the treated groups were significantly higher than those of the control group.In conclusion, the results of the present study demonstrated that moxidectin and ivermectin adminstered per os according to the manufacturer's instructions were both effective and safe anthelmintics in sheep. The total milk production was higher in the treated groups than the control group. Overall, animals treated with moxidectin had a milk production 40.8% higher than control group; whereas animals treated with ivermectin had a milk production 32.2% higher than control group.Gastrointestinal nematode (GIN) infection (caused by different genera of nematodes, e.g. Teladorsagia, Haemonchus, Bunostomum, Cooperia, Nematodirus, Trichostrongylus, Chabertia and Oesophagostomum) is one of the main constraints to livestock production both in temperate and tropical countries. In many cases, GIN parasitism can be attributed to a nutritional disease, because the presence of worms usually induces a decrease in appetite, a decreased digestibility of the food and a diversion of nutrients from production sites towards the repair of tissue-damage caused by the parasites. Therefore, economic losses caused by GIN are related to decreased production, treatment costs and even animal death.Control of these parasitic infections in ruminants relies almost exclusively on multiple and regular dosing with anthelmintics. Besides the parasitological efficacy of an anthelmintic treatment, it is very important to consider its strategic and economic benefits. Indeed, for producers the two primary aims of anthelmintic treatment strategies are firstly to maintain or improve animal performance and secondly to reduce pasture c
%U http://www.biomedcentral.com/1746-6148/5/41