%0 Journal Article
%T Infliximab in ulcerative colitis
%A Avi Levin
%A Oren Shibolet
%J Biologics: Targets and Therapy
%D 2008
%I Dove Medical Press
%X Avi Levin, Oren ShiboletGastroenterology and Liver Units, Division of Medicine, Hadassah-Hebrew University Medical center, Jerusalem, IsraelAbstract: Infliximab, a monoclonal anti-TNF-¦Á antibody, is commonly used for treatment of moderate to severe Crohn¡¯s disease (CD). Its role in the treatment for ulcerative colitis (UC) remains controversial. We review the role of TNF-¦Á in the pathogenesis of UC and describe the randomized, double-blind, placebo-controlled trials and systematic reviews that assess the efficacy of infliximab in the treatment of moderate to severe UC.Keywords: infliximab, ulcerative colitis, anti-TNF-¦Á antibody, crohn¡¯s disease
%U http://www.dovepress.com/infliximab-in-ulcerative-colitis-a2288