%0 Journal Article
%T Reproducibility and age-related changes of ocular parametric measurements in rabbits
%A Andri K Riau
%A Neil YS Tan
%A Romesh I Angunawela
%A Hla M Htoon
%A Shyam S Chaurasia
%A Jodhbir S Mehta
%J BMC Veterinary Research
%D 2012
%I BioMed Central
%R 10.1186/1746-6148-8-138
%X The growth of New Zealand White rabbits (n£¿=£¿16) were monitored from age 1 to 12 months old. Corneal keratometric and refractive values were obtained using an autorefractor/keratometer, and CCT was measured using an AS-OCT. Keratometry and CCT changed rapidly from 1 to 7 months and appeared to be stabilizing after 8 months. The reduction of corneal curvature was approximately 1.36 diopter (D)/month from age 1 to 7 months, but the change decelerated to 0.30 D/month from age 8 to 12 months. An increase of 10 ¦Ìm/month in CCT was observed from age 1 to 7 months, but the gain was reduced to less than 1 ¦Ìm/month from age 8 to 12 months. There was a hyperopic shift over the span of 12 months, albeit the increase in spherical equivalent was slow and gradual. Rabbits of random age were then selected for 2 repeated ACD and ACW measurements by 2 independent and masked observers. Bland-Altman plots revealed a good agreement of ACD and ACW measurements inter- and intra-observer and the ranges of 95% limit of agreement were acceptable from a clinical perspective.Corneal keratometry, spherical equivalent refraction and CCT changed significantly during the first few months of life of rabbits. Young rabbits have been used in a large number of eye research studies. In certain settings, the ocular parametric changes are an important aspect to note as they may alter the findings made in a rabbit experimental model. In this study, we have also demonstrated for the first time a good between observer reproducibility of measurements of ocular parameters in an animal model by using an AS-OCT.The rabbit has been a ubiquitous animal model for ocular research for decades. In the field of refractive surgery research in particular, the rabbit has been the ¡®go to¡¯ animal for evaluation of new techniques and drugs, as well as to better understand corneal wound healing responses. Refractive surgery has been rapidly evolving over last six decades [1,2]. Among the available refractive surgeries, lase
%K Cornea
%K Rabbit
%K Refractive
%K Keratometry
%K Anterior chamber
%K Reproducibility
%U http://www.biomedcentral.com/1746-6148/8/138