%0 Journal Article
%T Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis
%A Sarah Malek
%A Susannah J Sample
%A Zeev Schwartz
%A Brett Nemke
%A Peer B Jacobson
%A Elizabeth M Cozzi
%A Susan L Schaefer
%A Jason A Bleedorn
%A Gerianne Holzman
%A Peter Muir
%J BMC Veterinary Research
%D 2012
%I BioMed Central
%R 10.1186/1746-6148-8-185
%X Acute hyperthermia developed after ABT-116 treatment (P < 0.001). Treatment with carprofen (P ¡Ü 0.01) and tramadol (P ¡Ü 0.001) led to improved mobility assessed by owner questionnaire. Nighttime activity was increased after ABT-116 treatment (P = 0.01). Kinetic gait analysis did not reveal significant treatment effects. Use of rescue treatment decreased with treatment in the ABT-116 and Carprofen groups (P < 0.001). Questionnaire score and activity count at the end of treatment were correlated with age, clinical severity at trial entry, and outcome measure baseline status (SR ¡Ý ¡À0.40, P ¡Ü 0.005). Placebo treatment effects were evident with all variables studied.Treatment of hip OA in client-owned dogs is associated with a placebo effect for all variables that are commonly used for efficacy studies of analgesic drugs. This likely reflects caregiver bias or the phenomenon of regression to the mean. In the present study, outcome measures with significant effects also varied between groups, highlighting the value of using multiple outcome measures, as well as an a priori analysis of effect size associated with each measure. Effect size data from the present study could be used to inform design of future trials studying analgesic treatment of canine OA. Our results suggest that analgesic treatment with ABT-116 is not as effective as carprofen or tramadol for treatment of hip arthritis pain in client-owned dogs.Osteoarthritis (OA) is one of the most common orthopaedic diseases of dogs. It is a chronic condition associated with progressive destruction of joint tissues, including bone, cartilage, and synovium. Estimates in one study suggest that up to 20% of the adult canine population has some type of OA [1]. OA is common in the weight-bearing joints of medium to large-sized dogs, although it may affect any synovial joint. Arthritis secondary to hip dysplasia is particularly common. The prevalence of hip dysplasia varies in different breeds and in many large breeds exceeds
%K Dog
%K Hip
%K Osteoarthritis
%K Outcome measures
%K Clinical trial
%K Carprofen
%K Tramadol
%K ABT-116
%U http://www.biomedcentral.com/1746-6148/8/185