%0 Journal Article
%T Jellyfish mucin may have potential disease-modifying effects on osteoarthritis
%A Naoshi Ohta
%A Masato Sato
%A Kiminori Ushida
%A Mami Kokubo
%A Takayuki Baba
%A Kayoko Taniguchi
%A Makoto Urai
%A Koji Kihira
%A Joji Mochida
%J BMC Biotechnology
%D 2009
%I BioMed Central
%R 10.1186/1472-6750-9-98
%X In the C and M groups, macroscopic cartilage defects extended to the subchondral bone medially and laterally. When the H and both MH groups were compared, only minor cartilage degeneration was observed in groups treated with qniumucin in contrast to the group without qniumucin. Histologically, densely safranin-O-stained cartilage layers were observed in the H and two MH groups, but cartilage was strongly maintained in both MH groups.At the concentrations of qniumucin used in this study, injection together with HA inhibited articular cartilage degeneration in this model of OA.Osteoarthritis (OA) is one of the most common joint diseases and is characterized by the gradual degeneration of cartilage over a long time (regressive degeneration). This disease commonly develops in the weight-bearing joints of the lower limbs, such as the knee and hip joints, and onset shows a close correlation closely with age. OA is thus one of the main causes of pain and joint dysfunction among the elderly, and is also often seen in young people after traumas such as a fracture, anterior cruciate ligament transection (ACL-T), meniscus injury or in the presence of an underlying disease such as hemophilia [1]. Currently, pharmacotherapies for OA focus mainly on the alleviation of pain and consist of systemic analgesic therapies and local intra-articular treatments. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used as systemic analgesic therapies [2]. However, pathological progression of OA can be accelerated by the use of NSAIDs [3-6]. Similarly, hyaluronan (HA) injection therapy is a widely recognized part of local intra-articular treatments, inhibiting the destruction of articular cartilage by increasing the viscosity of synovial fluid [7-10].The presence of a thin membrane layer on the articular cartilage surface is believed to protect against external impact and reduce friction. This membrane is formed from glycoproteins with a mucin-type domain, some of which have been ident
%U http://www.biomedcentral.com/1472-6750/9/98