%0 Journal Article
%T Synthesis, Superoxide Dismutase Mimetic and Anticancer Activities of Metal Complexes of 2,2-Dimethylpentanedioic Acid(2dmepdaH 2 ) and 3,3-Dimethylpentanedioic acid(3dmepdaH 2 ): X-Ray Crystal Structures of [Cu(3dmepda)(bipy)] 2   6H 2 O and [Cu(2dmepda)(bipy)(EtOH)] 2  4EtOH( bipy=2, 2 ¡ä Bipyridine)
%A Michael Devereux
%A Malachy McCann
%A Denis O'Shea
%A Mark O'Connor
%J Bioinorganic Chemistry and Applications
%D 2006
%I Hindawi Publishing Corporation
%X 2,2-dimethylpentanedioic acid (2dmepda H 2 ) and 3,3-dimethylpentanedioic acid (3dmepda H 2 ) reacted with copper(II) acetate to give [Cu(2dmepda) ( H 2 O ) 3 ] 2 (1) and [Cu(3dmepda) ( H 2 O ) 3 ] 2 (2). Reaction of (1) and (2) with 1,10-phenanthroline and 2, 2 ¡ä -bipyridine yielded [Cu(2dmepda)(phen) ( H 2 O ) ] 2 0.5phen (3), [Cu(2dmepda)(bipy) ( H 2 O ) ] 2 (4), [Cu(2dmepda)(bipy)(EtOH)] 2  2EtOH (4A), [Cu(3dmepda)(phen) ( H 2 O ) ] 2 (5), and [Cu(3dmepda)(bipy) ( H 2 O ) ] 2   (6). The structures of (4A) and (6) each consists of a [Cu(bipy)(dicarboxylate) ( solvent ) ] 2 dimer. The superoxide dismutase (SOD) mimetic activity of the novel copper complexes and their manganese analogues was investigated. The dimethyl sulphoxide(DMSO) soluble complexes (1)¨C(4) and (6) were assessed for their cancer chemotherapeutic potential towards hepatocellular carcinoma and kidney adenocarcinoma cell lines. The 1,10-phenanthroline containing complex [Cu(2dmepda)(phen) ( H 2 O ) ] 2 0.5phen (3) was the most potent with activity that compares well to that of cisplatin.
%U http://www.hindawi.com/GetArticle.aspx?doi=10.1155/BCA/2006/80283