%0 Journal Article
%T Enhanced Ovarian Folliclular Development by Metformin Does Not Correlate with Pregnancy Rate: A Randomized Trial
%A Zahra Basirat
%A Mehrdad Kashifard
%A Masoumeh Golsorkhtabar Amiri
%J International Journal of Fertility & Sterility
%D 2012
%I Royan Institute
%X Background: Polycystic ovary syndrome (PCOS) is a common, complex endocrinedisorder for women of productive age. A high incidence of ovulation failure in womenwith PCOS is related to insulin resistance. Some studies have assessed the effects ofhyperinsulinemia and insulin resistance in relationship with insulin sensitizing agentssuch as Metformin (Met). These medicines have been suggested new scope for ovulationstimulation enhancement with Clomiphene Citrate (CC) in PCOs women. The aimof this study is to compare the effectiveness of adding Met to CC in women with PCOS.Materials and Methods: This multicenter, single-blind, randomized controlled trialstudy was performed on 334 PCOS patients from 2007 to 2009. Patients were randomlydivided into two groups and ovulation induction was performed with either CC alone orCC + Met. The treatment was continued for three cycles, then the mature follicle andpregnancy rates were evaluated.Results: In the CC + Met group, 68% had at least one dominant follicle in the first cyclethat was significant (p<0.001), and 31.7% had one in the second cycle. In the CC group54.5% in the first cycle, 31.7% second cycle, and 6.9% ovulated in the third cycle. Thepregnancy rate was 28.7% in CC + Met group and 24.6% in the CC group, with no significantdifferences between the two groups.
%K PCOS
%K Ovulation Induction
%K Metformin
%K Clomiphene Citrate
%U http://ijfs.ir/library/upload/article/af_54322437342258824466423433252675423226485-Basirat.pdf