%0 Journal Article
%T Evaluating of High Fructose Diet to Induce Hyperglycemia and its Inflammatory Complications in Rats
%A Aida Zarfeshani
%A Mohd Sokhini Abd Mutalib
%A Huzwah Khaza`ai
%J Pakistan Journal of Nutrition
%D 2012
%I 
%X It has been reported that a diet enriched in fructose would present animal models used to emulate diabetes mellitus type 2 in human. This study aimed to examine the effect of high fructose induction on the blood glucose, C-reactive protein, interleukin-6, interleukin-4 and body weight among high fructose diet-induced rats. The HFD was induced through drinking water in 21% (w/v) concentration among male Sprague-Dawley rats. The high fructose diet administration was unable to induce hyperglycemia, hypertriglyceridemia or any classic inflammatory markers. Also, no histological inflammation was observed. It was concluded that healthy Sprague-Dawley rats fed high fructose diet for 2.5 months could not develop signs of diabetes mellitus type 2.
%K High fructose diet
%K hyperglycemia
%K inflammatory biomarkers
%K Sprague-dawley rats
%U http://docsdrive.com/pdfs/ansinet/pjn/2012/21-26.pdf