%0 Journal Article
%T Allelic Prevalence of ABO Blood Group Genes in Iranian Azari Population
%A Mohammad Nojavan
%A Karim Shamsasenjan
%A Ali Akbar Movassaghpour
%A Parvin Akbarzadehlaleh
%J BioImpacts
%D 2012
%I Tabriz University of Medical Sciences
%X Introduction: ABO blood group system is the most important blood group in transfusion and has been widely used in population studies. Several molecular techniques for ABO allele¡¯s detection are widely used for distinguishing various alleles of glycosyl transferase locus on chromosome 9. Methods: 744 randomly selected samples from Azari donors of East Azerbaijan province (Iran) were examined using well-adjusted multiplex allele- specific PCR ABO genotyping technique. Results: The results were consistent for all individuals. The ABO blood group genotype of 744 healthy Azari blood donors was: 25.8% AA/AO (2), 7.6% AO (1), 1.6% BB, 11.3% B0 (1), 10% AB, 9.3% 0(1)0(1) and 15.3%0(1)0(2). The highest genotype frequency belonged to O01/O02 genotype (15.3%) and the lowest frequency belonged to A101/A102 genotype (0.4%). Conclusions: The frequencies of ABO alleles didn¡¯t show significant differences between East Azerbaijan province population and that of other areas of the country. Meanwhile, statistical analysis of frequencies of A and B alleles between East Azerbaijan province population and neighbor countries showed significant differences whereas the frequency of allele O between them did not show significant difference (P>0.05).
%K ABO Blood Groups
%K Genotyping
%K Multiplex Allele-Specific PCR
%K Iran
%U http://dx.doi.org/10.5681/bi.2012.016