%0 Journal Article
%T Hematopoietic stem cell transplantation
%A Eleftheria Hatzimichael
%A Mark Tuthill
%J Stem Cells and Cloning: Advances and Applications
%D 2010
%I Dove Medical Press
%X Eleftheria Hatzimichael1, Mark Tuthill21Department of Haematology, Medical School of Ioannina, University of Ioannina, Ioannina, Greece; 2Department of Medical Oncology, Hammersmith Hospital, Imperial College National Health Service Trust, London, UKAbstract: More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes. Before transplantation, patients receive intensive myeloablative chemoradiotherapy followed by stem cell ¡°rescue.¡± Autologous HSCT is performed using the patient¡¯s own hematopoietic stem cells, which are harvested before transplantation and reinfused after myeloablation. Allogeneic HSCT uses human leukocyte antigen (HLA)-matched stem cells derived from a donor. Survival after allogeneic transplantation depends on donor¨Crecipient matching, the graft-versus-host response, and the development of a graft versus leukemia effect. This article reviews the biology of stem cells, clinical efficacy of HSCT, transplantation procedures, and potential complications.Keywords: hematopoietic stem cell transplantation, complications
%U http://www.dovepress.com/hematopoietic-stem-cell-transplantation-a5132