%0 Journal Article
%T The effect of oral feeding of Allium ascalonicum L. on thoracic aorta contractile response in diabetic rats
%A Faramarz Fallahi
%A Mehrdad Roghani
%A Ali Bagheri
%J Koomesh
%D 2009
%I Semnan Univeristy of Medical Sciences
%X Introduction: Diabetes mellitus is accompanied with higher incidence of cardiovascular disorders.There is some evidence on antidiabetic potential of Allium ascalonicum L. (AA). Therefore, this studywas conducted to evaluate the beneficial effect of oral two-month administration of AA on contractilereactivity of isolated thoracic aorta from diabetic rats.Materials and Methods: Male Wistar rats were divided into control, AA-treated control, diabetic,and AA-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was intraperitoneallyadministered (60 mg/Kg). Meanwhile, treated groups received AA mixed with standard pelleted foodat a weight ratio of 6.25% for 2 months. Serum glucose level was measured in weeks 4 and 8. Alsoafter 2 months contractile reactivity of thoracic aortic rings to KCl and noradrenaline was determinedusing isolated tissue setup.Results: Serum glucose level showed a significant increase in diabetic animals (p<0.001) and thiswas significantly attenuated in AA-treated diabetic group (p<0.005). In addition, AA-treated diabeticgroup showed a lower contraction to KCl and noreadrenaline (p<0.05) as compared to diabetic group.Meanwhile, there was no significant difference between control and AA-treated control groupsregarding contractile reactivity.Conclusion: Oral administration of AA for 2 months could improve hyperglycemia and alsoattenuate the contractile responsiveness of the vascular system and this may prevent the developmentof hypertension in diabetic rats.
%K Allium ascalonicum L.
%K Aorta
%K Diabetes Mellitus
%K Contractile Response
%U http://www.koomeshjournal.ir/browse.php?a_code=A-10-4-368&slc_lang=en&sid=1&ftxt=1