%0 Journal Article
%T The influence of blood on the efficacy of intraperitoneally applied phospholipids for prevention of adhesions
%A Nick Butz
%A Stefan A M¨šller
%A Karl-Heinz Treutner
%A Michail Anurov
%A Svetlana Titkova
%A Alexander P Oettinger
%A Volker Schumpelick
%J BMC Surgery
%D 2007
%I BioMed Central
%R 10.1186/1471-2482-7-14
%X In 40 Chinchilla rabbits adhesions were induced by median laparotomy, standardized abrasion of the visceral and parietal peritoneum in defined areas of the ventral abdominal wall and the caecum. The animals were randomly divided into four groups. They received either phospholipids 3.0% or normal saline (NaCl 0,9%) (5 ml/kg body weight). In 50% of the rabbits we simulated intraperitoneal bleeding by administration of blood (1,5 ml/kg body weight). The other half served as control group. Ten days following the operation the animals were sacrificed and adhesion formation was assessed by computer aided planimetry and histopathologic examination.The median adhesion surface area in the NaCl-group (n = 9) amounted to 68,72 mm2, in the NaCl+Blood-group (n = 10) 147,68 mm2. In the Phospholipid (PhL)-group (n = 9) the median adhesion surface area measured 9,35 mm2, in the PhL+Blood-group (n = 9) 11,95 mm2. The phospholipid groups had a significantly smaller adhesion surface area (p < 0.05).Again these results confirm the efficacy of phospholipids in the prevention of adhesions in comparison to NaCl (p = 0,04). We also demonstrated the adhesion preventing effect of phospholipids in the presence of intraperitoneal blood.Postoperative peritoneal adhesions are frequent and serious sequelae after abdominal surgery. They cause recurrent and chronic complaints and pain as well as female infertility, and they increase the duration and complication rate of reoperations[1,2]. The incidence of postoperative peritoneal adhesions and their related complications are constantly rising parallel to increasing longevity and growing numbers of surgical procedures[3,4]. Today they are the most frequent cause of intestinal obstruction, account for 3% of all hospital admissions in general surgery, and are responsible for about 30% of all cases of female infertility. Intestinal obstruction as the most life threatening adhesion-related disease is associated with mortality rates of up to 15%[5,6]. Ad
%U http://www.biomedcentral.com/1471-2482/7/14