%0 Journal Article
%T A prospective cohort study to investigate cost-minimisation, of Traditional open, open fAst track recovery and laParoscopic fASt track multimodal management, for surgical patients with colon carcinomas (TAPAS study)
%A Jurrian C Reurings
%A Willem R Spanjersberg
%A Henk JM Oostvogel
%A Erik Buskens
%A John Maring
%A Flip Kruijt
%A Camiel Rosman
%A Peter van Duivendijk
%A Cees HC Dejong
%A Cees JHM van Laarhoven
%J BMC Surgery
%D 2010
%I BioMed Central
%R 10.1186/1471-2482-10-18
%X The Tapas-study is a three-arm multicenter prospective cohort study.All patients with colon carcinoma, eligible for surgical treatment within the study period in four general teaching hospitals and one university hospital will be included. This design produces three cohorts: Conventional open surgery is the control exposure (cohort 1). Open surgery with ERAS recovery (cohort 2) and laparoscopic surgery with ERAS recovery (cohort 3) are the alternative exposures. Three separate time periods are used in order to prevent attrition bias.Primary outcome parameters are the two main cost factors: direct medical costs (real cost price calculation) and the indirect non medical costs (friction method). Secondary outcome parameters are mortality, complications, surgical-oncological resection margins, hospital stay, readmission rates, time back to work/recovery, health status and quality of life.Based on an estimated difference in direct medical costs (highest cost factor) of 38% between open and laparoscopic surgery (alfa = 0.01, beta = 0.05), a group size of 3กม40 = 120 patients is calculated.The Tapas-study is three-arm multicenter cohort study that will provide a cost evaluation of three treatment programs for patients with colon carcinoma, which may serve as a guideline for choice of treatment and investment strategies in hospitals.ISRCTN44649165.The standard of care for colon carcinoma patients is changing. Traditionally operative treatment means an open resection (i.e. laparotomy) and 'conventional' patient-tailored recovery. In the last decade laparoscopic (assisted) colon surgery is introduced as a valuable alternative [1-5]. Over the last five years Enhanced Recovery After Surgery (ERAS) programs have been introduced and in many hospitals these alternatives gradually replace conventional care [6-11].Equality of long term clinical (and oncological) effectiveness of laparoscopic surgery as well as ERAS recovery has been proven in literature [4,5,12-18]. To date however,
%U http://www.biomedcentral.com/1471-2482/10/18