%0 Journal Article
%T Dosagens s¨¦ricas de prote¨ªna C-reativa na fase inicial da sepse abdominal e pulmonar Serum C-reactive protein concentrations in early abdominal and pulmonary sepsis
%A Juliane Agustini Orati
%A Patricia Almeida
%A Vanessa Santos
%A Gustavo Ciorla
%J Revista Brasileira de Terapia Intensiva
%D 2013
%I Associa??o de Medicina Intensiva Brasileira
%X OBJETIVO: Avaliar os n¨ªveis s¨¦ricos de prote¨ªna C-reativa em pacientes com sepse pulmonar e abdominal nos primeiros 5 dias de progress o da sepse. M¨¦TODOS: Estudo de coorte retrospectivo em hospital universit¨¢rio. Foram selecionados 345 pacientes admitidos em unidade de terapia intensiva e diagnosticados com sepse de origem pulmonar ou abdominal. A dosagem s¨¦rica de prote¨ªna C-reativa foi realizada por imunoensaio turbidim¨¦trico. Para an¨¢lises da prote¨ªna C-reativa, o dia 1 foi definido como o do diagn¨®stico cl¨ªnico da sepse. RESULTADOS: Foram avaliados 34 pacientes com sepse (9,8%), 114 com sepse grave (33,0%) e 197 com choque s¨¦ptico (57,2%). A idade dos pacientes foram 56,4¡À19,8 anos. Concentra  es s¨¦ricas de prote¨ªna C-reativa foram mais elevadas no dia do diagn¨®stico de sepse no grupo com infec  o de origem abdominal em compara  o ao grupo com sepse pulmonar (17,8¡À10,1 mg/dL versus 14,9¡À11,1 mg/dL; p=0,025) e mantiveram-se significativamente mais elevadas nos primeiros 5 dias de evolu  o da sepse. CONCLUS O: As concentra  es s¨¦ricas de prote¨ªna C-reativa foram significativamente mais elevadas nos pacientes com sepse de origem abdominal do que em pacientes com sepse de origem pulmonar nos 5 primeiros dias de evolu  o da sepse. OBJECTIVES: To evaluate the C-reactive protein serum levels in patients with pulmonary and abdominal sepsis during the first five days of sepsis progression. METHODS: The present investigation was a retrospective cohort study conducted at the university hospital with 345 patients who were admitted to the intensive care unit and diagnosed with sepsis of pulmonary or abdominal origin. Serum C-reactive protein concentrations were measured by the turbidimetric immunoassay. For analysis of C-reactive protein, day 1 was defined as the day on which the patient was clinically diagnosed with sepsis. RESULTS: Thirty-four patients with sepsis (9.8%), 114 patients with severe sepsis (33.0%), and 197 patients with septic shock (57.2%) were evaluated. The age of the patients was 56.4¡À19.8 years. The serum C-reactive protein concentrations were higher on the day of sepsis diagnosis in the group with abdominal infection compared with the group with pulmonary sepsis (17.8¡À10.1 mg/dL versus 14.9¡À11.1 mg/dL, p=0.025) and remained significantly higher during the first five days of sepsis progression. CONCLUSION: The serum C-reactive protein concentrations were significantly higher in the patients with abdominal sepsis compared with the patients with pulmonary sepsis during the first five days of sepsis progression.
%K Prote¨ªna c-reativa
%K Sepse
%K Marcadores biol¨®gicos
%K C-reactive protein
%K Sepsis
%K Biological markers
%U http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-507X2013000100003