%0 Journal Article
%T Escorpionismo del g谷nero Tityus en la sierra falconiana y su correlaci車n con la liberaci車n de mediadores inflamatorios y enzimas card赤acas
%A Alejandro Guinand
%A Hernando Cort谷s
%A Gina D∩Suze
%A Patricia D赤az
%J Gaceta M谷dica de Caracas
%D 2004
%I Scientific Electronic Library Online
%X Se identificaron cinco especies de escorpiones en la sierra falconiana, de los cuales s車lo Tityus falconensis Gonz芍lez Sponga, 1974, estuvo asociado a los casos con sintomatolog赤a sist谷mica de escorpionismo. Se estudiaron 15 pacientes de escorpionismo, encontr芍ndose que la venenemia, interleuquina-6, factor de necrosis tumoral alfa, el 車xido n赤trico y la creatinfosfokinasa MB aumentaron con la gravedad del accidente. Esto sustenta el papel que juegan las toxinas escorpi車nicas en la activaci車n de los mecanismos inflamatorios. El aumento de la creatinfosfokinasa MB durante las dos primeras horas del accidente sugiere que T. falconensis presenta toxinas cardiot車xicas. Los valores de glicemia y amilasa plasm芍tica no se alteraron; adem芍s se observ車 que 3 pacientes mostraron tiempos de coagulaci車n alterados. Five scorpion species were identified at the Falcon State mountain but only Tityus falconensis was associated with the cases that developed a systemic symptomatology. In the 15 patients studied we found that venenemia, nitric oxide, interleukin-6, tumor necrosis factor-alpha and creatinphosphoquinase increased with the severity of the sting. This study reveals the role of scorpion toxins on the activation of the inflammatory response. Increases of the creatinphosphoquinase-MB during the first 2 hours after the accident, suggest that T. falconensis content abundant cardiotoxic toxins. We observed that glycemia and amylase were not altered by these venom and 3 of the patients studied showed altered coagulation times.
%K Escorpionismo
%K Venenemia
%K Interleuquinas
%K 車xido n赤trico
%K Scorpionism
%K Venenemia
%K Cytokines
%K Nitric oxide
%K Creatinphosphoquinase-MB
%U http://wwww.scielo.org.ve/scielo.php?script=sci_arttext&pid=S0367-47622004000200006