%0 Journal Article
%T The incidence of venous thromboembolism in cervical cancer: a nationwide population-based study
%A Shiang-Jiun Tsai
%A Ying-Xu Ruan
%A Ching-Chih Lee
%A Moon-Sing Lee
%A Wen-Yen Chiou
%A Hon-Yi Lin
%A Feng-Chun Hsu
%A Yu-Chieh Su
%A Shih-Kai Hung
%J BMC Research Notes
%D 2012
%I BioMed Central
%R 10.1186/1756-0500-5-316
%X The study analyzed data deposited between 2003 and 2008 in the National Health Insurance Research Database (NHIRD), provided by the National Health Research Institutes in Taiwan. Totally, 1013 cervical cancer patients after treatment and 2026 appendectomy patients were eligible. The Kaplan-Meier method and the Cox proportional hazards model were used to assess the VTE risk.The 5-year cumulative risk for VTE was significantly higher in the cervical cancer group than in the control group (3.3% vs 0.3%, p£¿<£¿0.001). The hazard ratio for VTE was 10.14 times higher in the cervical cancer group than in the controls. The combined presence of more comorbidities was associated with a higher risk for VTE. Furthermore, cervical cancer patients without VTE had a significantly higher survival (75.3% vs 30.3%, p£¿<£¿0.001).The cumulative risk of VTE was significantly higher in cervical cancer patients, and these patients also had lower survival rates. Strategies to reduce these risks need to be examined.Cervical cancer remains the most important malignant disease in women, with an age-adjusted incidence of 26.2 per one hundred thousand people in Taiwan.[1] Venous thromboembolism (VTE) is a life-threatening condition in cervical cancer. Its incidence can be stratified by patient, tumor, or treatment. Reports of the VTE incidence in cervical cancer vary, and range from 0% to 34%.[2] For cancer-related VTE, the incidence of VTE is higher in the first few months after cancer is diagnosed, and subsequently decreases with time.[3,4] A literature review indicates that surgery, chemotherapy, or radiotherapy can be risk factors for VTE.[5] Radiation-induced vascular disease has been reported. Concurrent chemotherapy and radiotherapy is the standard treatment for patients with advanced cervical cancer, and it increases survival.[6] Although the number of long-term survivors has increased, data on the incidence of radiotherapy- or chemotherapy-induced VTE remains limited. Thus, the aim of this
%U http://www.biomedcentral.com/1756-0500/5/316