%0 Journal Article
%T Specific cutaneous histologic and immunologic features in a case of early lupus erythematosus scarring alopecia
%A Ana Maria Abreu Velez
%A A. Deo Klein
%A Michael S. Howard
%J Our Dermatology Online
%D 2013
%I Our Dermatology Online
%X Introduction:Immunoreactants detected by direct immunofluorescence (DIF) in the skin of patients with lupus erythematosus represent an important tool in the diagnosis of this disorder. Case report: A 46 year old African American female presented complaining of hair loss and scarring in her scalp.Methods: Biopsies for hematoxylin and eosin (H&E) examination, as well as for direct immunofluorescence (DIF) were performed.Results: The histologic features were representative of early lupus erythematosus. DIF demonstrated immune deposits of several immunoglobulins and complement, primarily around skin appendageal structures(hair follicles and sweat glands). Deposits of immunoglobulin D were seen in several areas of the epidermis.Conclusion: In lupus erythematosus, evaluation of immune reactions against cutaneous appendageal structures may be crucial in differentiating this disorder from other autoimmune and non-autoimmune diseases.
%K discoid lupus erythematosus (DLE)
%K scarring alopecia
%K direct immunofluorescence(DIF)
%K skin appendices
%K lichen planopilaris (LPP)
%U http://www.odermatol.com/issue-in-html/2013-2-14-specific/