%0 Journal Article
%T Conjunctival mass as an initial presentation of mantle cell lymphoma: a case report
%A Mahsa Khanlari
%A Babak Bagheri
%A Reza Vojdani
%A Mohammad Mohammadianpanah
%A Shahram Paydar
%A Yahya Daneshbod
%J BMC Research Notes
%D 2012
%I BioMed Central
%R 10.1186/1756-0500-5-671
%X Most ocular adnexal lymphomas are extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT). A few cases of ocular adnexal mantle cell lymphomas have been reported in the literature. We present a case of mantle cell lymphoma presenting as right conjunctival mass of at least three months duration in a 64-year-old man. Histopathologic examination showed a proliferation of monomorphous small-to-medium-sized lymphoid cells with cleaved nuclei in the subconjunctiva. By immunohistochemistry, the infiltrate was positive for CD20, CD5, BCL-2, cyclin D1, and the transcription factor SOX11. Fluorescent in situ hybridization demonstrated the presence of IGH-CCND1 fusion indicating t(11;14).A rigorous approach to initial diagnosis and staging of small cell lymphomas of the ocular adnexa is needed. The recognition of ocular MCL requires appropriate immunohistochemical staining and/or genetic confirmation to differentiate this rare form of presentation of MCL from other more frequent small cell lymphomas.Ocular adnexal lymphomas (OALs) are the most common orbital neoplasms in adults, accounting for about 55% of all malignant orbital lesions [1,2]. About 80¨C90% of primary ocular adnexal lymphomas are extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue (MALT), which can arise within the intraconal and extraconal orbital fat, lacrimal gland, extraocular muscles, lacrimal sac, lids or conjunctiva [3]. Mantle cell lymphoma (MCL) is a relatively rare lymphoma, accounting for less than 10% of all lymphomas. In the ocular adnexal region, including rare cases of conjunctiva, MCL accounts for between 1-5% [4] and 9% of the lymphomas [5]. The orbit is the most commonly involved site of MCL involvement, followed by the lacrimal gland and the eyelid, similar to extranodal marginal zone lymphoma in this region [6]. Mantle cell lymphomas presenting in the ocular adnexal region have a male predominance and are associated with extraorbital ex
%K Lymphoma
%K Orbit
%K Conjunctiva
%K Mantle cell lymphoma
%K t(11
%K 14)
%K SOX 11
%U http://www.biomedcentral.com/1756-0500/5/671