%0 Journal Article
%T LOCAL EFFECTS OF GROWTH HORMONE ON INTACT CONDRO-COSTAL CARTILAGE
%A A Radulescu
%A IA Szucsik
%A ES Boia
%A CM Popoiu
%J Jurnalul Pediatrului
%D 2005
%I Fundatiei Profilaxis
%X Pectus excavatum is the most common chest wall deformity seen in children.We are trying to develop a new nonsurgical method of correcting the deformity.The local and systemic effects of human growth hormone ( Norditropin ) injected at the surface of intact condro-costal cartilage in 9 two weeks old Sprague Dawley rats were investigated.The cartilages were injected every two days for 21 days.Every second day one of the subjects was sacrified and the injected condro-costal cartilage site, tibial bone and mandibula were histologicaly analyzed. At the level of the tibial bone and mandibula no systemic effects of the growth hormone was found. Histological analysis confirmed the presence of ossification and calus formation at the site of injection andmodified shape of the cartilage. A local increase in periosteal bone deposition and new bone formed was found after transversal sections of the condro-costal cartilage were performed. Further studies will conclude if the local injectionof growth hormone in the cartilage will open a new gate  n the treatment of this malfomation.
%K condro-costal cartilage
%K periosteal bone
%K pectus excavatum
%U http://jurnalulpediatrului.ro/pages/detaliu.php?articol=Pediatric-IV-10&revista=29-30