%0 Journal Article
%T Modified Genetic Algorithm for DNA Sequence Assembly by Shotgun and Hybridization Sequencing Techniques
%A Prof.Narayan Kumar Sahu
%A Prof.Somesh Dewangan
%A Prof.Akash Wanjari
%J International Journal of Electronics and Computer Science Engineering
%D 2012
%I Buldanshahr : IJECSE
%X Since the advent of rapid DNA sequencing methods in 1976, scientists have had the problem of inferring DNA sequences from sequenced fragments. Shotgun sequencing is a well-established biological and computational method used in practice. Many conventional algorithms for shotgun sequencing are based on the notion of pair wise fragment overlap. While shotgun sequencing infers a DNA sequence given the sequences of overlapping fragments, a recent and complementary method, called sequencing by hybridization (SBH), infers a DNA sequence given the set of oligomers that represents all sub words of some fixed length, k. In this paper, we propose a new computer algorithm for DNA sequence assembly that combines in a novel way the techniques of both shotgun and SBH methods. Based on our preliminary investigations, the algorithm promises- to be very fast and practical for DNA sequence assembly [1].
%K DNA
%K Shotgun
%K Hybrid
%U http://www.ijecse.org/wp-content/uploads/2012/08/Volume-1Number-4PP-2000-2007.pdf