%0 Journal Article
%T An improved and efficient synthesis of Irbesartan, an antihypertensive drug
%A Somisetti Narender Rao
%A K. Sudhakar Babu
%J Organic Communications
%D 2011
%I ACG Publications
%X Development of a new improved and efficient process suitable for the large-scale production of Irbesartan has been described. The key steps are tetrazole formation from secondary amide for the preparation of the key intermediate 1-Benzyl-5-(4'-bromomethyl-biphenyl-2-yl)-1H-tetrazole (9), N-alkylation and debenzylation.
%K Irbesartan
%K antihypertensive drug
%K tetrazole formation
%K debenzylation.
%U http://www.acgpubs.org/OC/2011/Volume%204/Issue%201/13-OC-1106-199.pdf